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URL of this page: https://medlineplus.gov/druginfo/meds/a682198.html

Diphtheria, Tetanus, Pertussis (DTap) Vaccine

Why get vaccinated?

Diphtheria, tetanus, and pertussis (DTaP) vaccine may prevent diphtheria, tetanus, and pertussis that may occur with infection due to C. diphtheriae (diphtheria), C. tetani (tetanus), and B. pertussis (pertussis).

Infection with C. diphtheriae can cause diphtheria (difficulty breathing and life-threatening heart failure and paralysis), infection with C. tetani can cause tetanus (painful stiffening of the muscles), and infection with B. pertussis can cause whooping cough (a respiratory disease with severe coughing episodes).

Diphtheria, tetanus, and pertussis (DTaP) vaccine does not contain active bacteria. The vaccine works by triggering the body to make antibodies against the toxins produced by these bacteria to provide a defense against potential infection.The vaccine works by triggering the body to make antibodies against the toxins produced by these bacteria to provide a defense against potential infection.

How is the vaccine given?

Diphtheria, tetanus, pertussis vaccine comes as a suspension (liquid) to be given intramuscularly (into a muscle) by a healthcare provider.

Diphtheria, tetanus, pertussis vaccine is given as 5 doses given at 2, 4, 6, 15 to 20 months of age, and at 4-6 years of age.

What should you tell the person who is giving the vaccine?

Tell your vaccine provider if you:

  • have had an allergic reaction to this vaccine, any part of this vaccine, any other vaccine or any drug, food or substance. Tell your vaccine provider about the allergy and what symptoms you had.
  • had encephalopathy (decreased consciousness, seizures, coma) within 7 days to a previous dose of pertussis containing vaccine, had a nervous system condition (spams or seizures), or are at risk for seizures. Your doctor will likely tell you that you can not receive another pertussis-containing vaccine.
  • are immunocompromised or are receiving immunosuppressive medications, had Guillain-Barré syndrome (a nervous system disorder) within six weeks of a previous dose of tetanus containing vaccine, or have had a history of any of the following occurring after receiving a pertussis-containing vaccine: fever, persistent, inconsolable crying for 3 hours or more, seizures, collapse or loss of consciousness.

In some cases, your health care provider may decide to postpone vaccination to a future visit.

What are the risks from vaccination?

Side effects that have been reported with diphtheria, tetanus, pertussis vaccine include:

  • redness, tenderness, swelling at the site of injection
  • fever
  • irritability, fussiness, crying
  • tiredness, decreased activity

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • rash, hives, difficulty breathing or swallowing
  • seizures or other nervous system changes

People sometimes faint after medical procedures, including vaccination. Tell your provider if you feel dizzy or have vision changes or ringing in the ears.

Adverse reactions should be reported to the Vaccine Adverse Event Reporting System (VAERS). Your health care provider will usually file this report, or you can do it yourself. Visit https://vaers.hhs.gov or call 1-800-822-7967. VAERS is only for reporting reactions, and VAERS staff members do not give medical advice.

How can I learn more?

Brand names

  • Daptacel®
  • Infanrix®
Last Revised - 07/15/2026