Lerodalcibep-liga Injection

Lerodalcibep-liga injection is used to lower cholesterol (fat-like substance that can build up and clog blood vessels causing heart attack or stroke or other health condition). Lerodalcibep-liga is in a class of medications called proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor monoclonal antibodies. It works by stopping the production of cholesterol.

Lerodalcibep-liga injection comes as a solution (liquid) in a prefilled syringe to inject subcutaneously (just under the skin). It is injected once a month.

Use lerodalcibep-liga injection exactly as directed. Do not use more or less of this medication or use it more often or for a longer period of time than prescribed by your doctor.

Your first dose of lerodalcibep-liga injection will be given in your doctor's office. After that, you may be allowed to inject the medication yourself or have a caregiver give the injections. Carefully read the written instructions that come with it. Talk to your doctor or pharmacist if you have any questions on how to inject the medication.

Remove the syringe from the refrigerator. Allow the syringe to warm to room temperature for 30 minutes before using. Do not warm the medication in hot water, microwave, or place it in sunlight.

Inject lerodalcibep-liga on the front of your thighs or stomach area, except for the 2-inch area around your navel (belly button). If a caregiver is giving the injection, the back of the upper arm can be used. Use a different spot for each injection. Do not inject into a spot that is tender, bruised, red, hard, or areas with scars or stretch marks.

Before you use lerodalcibep-liga injection, look at the solution closely. The medication should be clear to brownish-yellow and free of floating particles. Do not use lerodalcibep-liga injection if it is cloudy or contains flakes or solid particles. Do not shake it.

Use each injection only once and inject all of the solution in the syringe. Dispose of used needles, syringes, and devices in a puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.

Lerodalcibep-liga injection helps to control cholesterol levels, but it does not cure this condition. Continue to use lerodalcibep-liga injection even if you feel well. Do not stop using lerodalcibep-liga injection without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before using lerodalcibep-liga injection,

• tell your doctor or pharmacist if you are allergic to this medication, any part of this medication, or any other medications, foods or substances. Tell your doctor or pharmacist about the allergy and what symptoms you had.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take.
• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using lerodalcibep-liga injection, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

If it is within 7 days of the missed dose, inject it as soon as you remember it and continue your regular dosing schedule. If it is more than 7 days from your missed dose, skip it and continue your regular dosing schedule. Start your new monthly schedule from this new date.

Call your doctor if you miss a dose and have questions about what to do.

Lerodalcibep-liga injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

• redness, itching, swelling, pain, bruising, or tenderness at the injection site
• runny or stuffy nose
• sore throat
• nausea
• diarrhea
• swelling in the arms, hands, legs, or feet

Lerodalcibep-liga injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (https://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it in the original carton in the refrigerator, protected from light. Do not freeze. Lerodalcibep-liga injection may also be kept at room temperature in the original carton for up to 30 months.

Keep all medication out of sight and reach of children as many containers are not child-resistant. Always lock safety caps. Place the medication in a safe location – one that is up and away and out of their sight and reach. https://www.upandaway.org

Dispose of unneeded medications in a way so that pets, children, and other people cannot take them. Do not flush this medication down the toilet. Use a medicine take-back program. Talk to your pharmacist about take-back programs in your community. Visit the FDA's Safe Disposal of Medicines website https://goo.gl/c4Rm4p for more information.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to lerodalcibep-liga injection.

Keep a written list of all of the prescription and nonprescription (over-the-counter) medicines, vitamins, minerals, and dietary supplements you are taking. Bring this list with you each time you visit a doctor or if you are admitted to the hospital. You should carry the list with you in case of emergencies.

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