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COPD - control drugs

Control medicines for chronic obstructive pulmonary disease (COPD) are medicines you take every day to control or prevent symptoms of COPD.

These medicines are not used to treat flare-ups. Flare-ups are treated with quick-relief (rescue) medicines.

Depending on the medicine, control medicines help you breathe easily by:

  • Relaxing the muscles in your airways
  • Reducing any swelling in your airways
  • Helping your lungs work better

You and your health care provider can make a plan for the control medicines that you should use. This plan will include when you should take them and how much you should take.

You may need to take these medicines for at least a month before you start to feel better. Take them even when you feel OK.

Ask your provider about the side effects of any medicines you are prescribed. Be sure you know which side effects are serious enough that you need to call your provider right away.

Follow instructions on how to use your medicines the right way.

Make sure you get your medicine refilled before you run out.

Anticholinergic Inhalers

Anticholinergic inhaled medicines include:

  • Aclidinium (Tudorza Pressair)
  • Glycopyrronium
  • Tiotropium (Spiriva)
  • Umeclidinium (Incruse Ellipta)
  • Revefenacin (Yupelri) is a long acting nebulized medicine

Use your anticholinergic inhalers every day, even if you do not have symptoms.

Beta-agonist Inhalers

Beta-agonist inhaled medicines include:

  • Salmeterol (Serevent)
  • Olodaterol (Striverdi Respimat)

Do not use a spacer with beta-agonist inhalers.

Inhaled Corticosteroids

Inhaled corticosteroids include:

  • Beclomethasone (Qvar Redihaler)
  • Ciclesonide (Alvesco)
  • Mometasone (Asmanex)
  • Budesonide (Pulmicort can be used in an inhaler or as a nebulized solution)

After you use these medicines, rinse your mouth with water, gargle, and spit.

Combination Inhaled Medicines

Combination medicines combine two or three medicines and are inhaled. They include (list is not complete):

  • Albuterol and ipratropium (Combivent Respimat)
  • Budesonide and formoterol (Symbicort)
  • Fluticasone and salmeterol (Advair)
  • Fluticasone and vilanterol (Breo Ellipta)
  • Formoterol and mometasone (Dulera)
  • Tiotropium and olodaterol (Stiolto Respimat)
  • Umeclidinium and vilanterol (Anoro Ellipta)
  • Glycopyrrolate and formoterol (Bevespi Aerosphere)
  • Fluticasone and umeclidinium and vilanterol (Trelegy Ellipta)
  • Budesonide and glycopyrrolate and formoterol (Breztri Aerosphere)

For all these medicines, some generic forms have just become or will become available in the near future, thus different names might also exist.

Phosphodiesterase Inhibitor

Roflumilast (Daliresp) is a tablet that is swallowed.

Ensifentrine (Ohtuvayre) is a medicine that is used in a nebulizer.

Antibiotics

Azithromycin is a tablet that is swallowed.

Systemic Corticosteroids

For some people with COPD, oral steroids are prescribed for daily use. This is a treatment of last resort because steroids have serious side effects when they are taken every day. In such cases, the lowest possible dose should be prescribed.

Alternative Names

Chronic obstructive pulmonary disease - control drugs; Bronchodilators - COPD - control drugs; Beta agonist inhaler - COPD - control drugs; Anticholinergic inhaler - COPD - control drugs; Long-acting inhaler - COPD - control drugs; Corticosteroid inhaler - COPD - control drugs

References

Global Initiative for Chronic Obstructive Lung Disease (GOLD) website. Global strategy for prevention, diagnosis and management of COPD: 2026 report. goldcopd.org/2026-gold-report-and-pocket-guide/. Accessed June 16, 2026.

Han MK, Lazarus SC. COPD: diagnosis and management. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. 7th ed. Philadelphia, PA: Elsevier; 2022:chap 64.

Nici L, Mammen MJ, Charbek E, et al. Pharmacologic management of chronic obstructive pulmonary disease. An Official American Thoracic Society Clinical Practice Guideline. Am J Respir Crit Care Med. 2020;201(9):e56-e69. PMID: 32283960 pubmed.ncbi.nlm.nih.gov/32283960/.

Reilly J. Chronic obstructive pulmonary disease. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 76.

US Department of Veterans Affairs website. VA/DoD Clinical Practice Guideline for the management of chronic obstructive pulmonary disease, Version 3.0, April 2021. www.healthquality.va.gov/HEALTHQUALITY/guidelines/CD/copd/VADODCOPDCPGFinal508.pdf. Accessed June 16, 2026.

Read More

Patient Instructions

Review Date 5/4/2026

Updated by: Andrew Schriber, MD, FCCP, Specialist in Pulmonary, Critical Care, and Sleep Medicine, Virtua Memorial Hospital, Mount Holly, New Jersey. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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