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Estrogen overdose

Estrogen is a female hormone. Estrogen overdose occurs when someone takes more than the normal or recommended amount of a product containing the hormone. This can be by accident or on purpose.

This article is for information only. DO NOT use it to treat or manage an actual overdose. If you or someone you are with has an overdose, call the local emergency number (such as 911), or the local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States.

Poisonous Ingredient

Estrogen

Where Found

Estrogen is an ingredient in birth control pills and hormone replacement therapy products.

Symptoms

Symptoms of an estrogen overdose include:

  • Breast tenderness
  • Discolored urine
  • Emotional changes
  • Drowsiness
  • Excessive vaginal bleeding (2 to 7 days after overdose)
  • Fluid retention
  • Headache
  • Nausea and vomiting
  • Skin rash

Home Care

Seek medical help right away. Do NOT make the person throw up unless poison control or a health care provider tells you to.

Before Calling Emergency

Have this information ready:

  • Person's age, weight, and condition
  • The name of the product (ingredients and strength, if known)
  • When it was swallowed
  • The amount swallowed
  • If the medicine was prescribed for the person

Poison Control

The local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. They will give you further instructions.

This is a free and confidential service. All local poison control centers in the United States use this national number. You should call if you have any questions about poisoning or poison prevention. It does NOT need to be an emergency. You can call for any reason, 24 hours a day, 7 days a week.

You can also get online poison help now at Poisonhelp.org. Just enter the product, poison, or medicine to get expert help.

What to Expect at the Emergency Room

If you go to the emergency room, take the medicine container with you, if possible.

The provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure.

Tests that may be done include:

  • Blood and urine tests

Treatment may include:

  • Activated charcoal (in extreme cases)
  • Intravenous fluids (IV, given through a vein)
  • Medicine to treat symptoms and reverse the effect of the drug

Outlook (Prognosis)

Serious symptoms are very unlikely.

References

Aronson JK. Estrogens. In: Aronson JK, ed. Meyler's Side Effects of Drugs. 16th ed. Waltham, MA: Elsevier; 2016:122-151.

Meehan TJ. Care of the poisoned patient. In: Walls RM, ed. Rosen's Emergency Medicine: Concepts and Clinical Practice. 10th ed. Philadelphia, PA: Elsevier; 2023:chap 135.

Review Date 7/1/2025

Updated by: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.

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