Cholestasis

There are many causes of cholestasis.

Extrahepatic cholestasis occurs outside the liver. It can be caused by:

• Bile duct tumors
• Cysts affecting the bile duct
• Narrowing of the bile duct (strictures)
• Stones in the common bile duct
• Pancreatitis
• Pancreatic tumor or pseudocyst
• Pressure on the bile ducts due to a nearby mass or tumor
• Primary sclerosing cholangitis

Intrahepatic cholestasis occurs inside the liver. It can be caused by:

• Alcoholic liver disease
• Amyloidosis
• Bacterial abscess in the liver
• Being fed exclusively through a vein (IV)
• Lymphoma
• Pregnancy
• Primary biliary cholangitis (previously called primary biliary cirrhosis)
• Primary or metastatic liver cancer
• Primary sclerosing cholangitis
• Sarcoidosis
• Serious infections that have spread through the bloodstream (sepsis)
• Tuberculosis
• Viral hepatitis

Certain medicines can also cause cholestasis, including:

• Antibiotics, such as ampicillin and other penicillins including amoxicillin-clavulanate
• Anabolic steroids
• Birth control pills
• Chlorpromazine
• Cimetidine
• Estradiol
• Imipramine
• Immune checkpoint inhibitors
• Prochlorperazine
• Terbinafine
• Tamoxifen
• Some chemotherapy agents
  

Symptoms may include:

• Clay-colored or pale stools
• Dark urine
• Inability to digest certain foods
• Itching
• Nausea or vomiting
• Pain in the right upper part of the abdomen
• Yellow skin or eyes

Blood tests may show that you have elevated bilirubin and alkaline phosphatase. They are also used to check for other liver conditions and assess how diseased your liver is.

You may need a liver biopsy.

Imaging tests are used to diagnose this condition. Tests include:

• CT scan of the abdomen
• MRI of the abdomen
• Magnetic resonance cholangiopancreatography (MRCP)
• Endoscopic retrograde cholangiopancreatography (ERCP), can also determine cause
• Ultrasound of the abdomen
• DEXA scan of your bones in certain types of cholestasis

The underlying cause of cholestasis must be treated. There are medicines to help the itching and other side effects of cholestasis.

How well a person does depends on the disease causing the condition. Stones in the common bile duct can often be removed. This can cure the cholestasis.

Stents can be placed to open areas of the common bile duct that are narrowed or blocked by cancers.

If the condition is caused by the use of a certain medicine, it will often go away when you stop taking that medicine.

Occasionally a liver transplant is needed in severe cases.

Complications may include:

• Diarrhea
• Organ failure can occur if sepsis develops
• Poor absorption of fat and fat-soluble vitamins
• Severe itching
• Weak bones (osteomalacia) due to having cholestasis for a very long time

Contact your health care provider if you have:

• Itching that does not go away
• Yellow skin or eyes
• Other symptoms of cholestasis

Get vaccinated for hepatitis A and B if you are at risk. Do not use intravenous drugs and share needles.

Intrahepatic cholestasis; Extrahepatic cholestasis

Fogel EL, Sherman S. Diseases of the gallbladder and bile ducts. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 141.

Levy C, Bowlus CL. Primary biliary cholangitis. In: Chung RT, Rubin DT, Wilcox CM, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 12th ed. Philadelphia, PA: Elsevier; 2026:chap 93.

Lidofsky SD. Jaundice. In: Chung RT, Rubin DT, Wilcox CM, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 12th ed. Philadelphia, PA: Elsevier; 2026:chap 22.

Martin P. Approach to the patient with liver disease. In: Goldman L, Cooney KA, eds. Goldman-Cecil Medicine. 27th ed. Philadelphia, PA: Elsevier; 2024:chap 132.

Updated by: Todd Eisner, MD, Private practice specializing in Gastroenterology in Boca Raton and Delray Beach, Florida at Gastroenterology Consultants of Boca Raton. Affiliate Assistant Professor, Florida Atlantic University School of Medicine. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.